A synthetic cannabis compound created by Dr. Raphael Mechoulam, the man who first identified THC, is said to be more potent than THC and CBD, and could help treat anxiety, inflammatory diseases, and nausea.
Last fall, Dr. Raphael Mechoulam, the Israeli innovator known as the “Godfather of cannabis research,” announced the creation of cannabidiolic acid methyl ester (EPM301), a synthetic cannabinoid that is far more potent than THC or CBD. Now, after several months of testing, researchers have found that this new compound could be a powerful treatment for nausea, anxiety, and inflammatory disorders.
EPM301, which was developed and patented by Dr. Mechoulam and a team of researchers from US-based biotech firm EPM, is a synthetic version of a natural acid that occurs within the cannabis plant. In addition to cannabis compounds like THC, CBD, and terpenes, living cannabis plants contain a variety of acids, such as THC-A or CBD-A. These acids are far more potent than their more well-known counterparts, but they are also highly unstable.
For years, this instability has prevented researchers from successfully isolating these acids from living plants and using them for medicinal purposes. But last September, Dr. Mechoulam and EPM announced that they had figured out a way to modify these acids to make them stable. To accomplish this feat, researchers used a process called esterification, in which two separate chemicals combine to form a stable compound called an ester.